Outpatient Parenteral Antibiotic Therapy (OPAT): Peripherally Inserted Central Catheter (PICC) Download PDF, 1.04MB, PDF You need long-term access to the veins for the following treatments: Antibiotics Chemotherapy Total Parenteral Nutrition (nutrition administered through the veins) A Peripherally Inserted Central Catheter (PICC) is a long, thin, soft and flexible tube that is inserted into your body through a large vein, usually in the upper arm. The PICC may have a single or double lumen, meaning that it can come in single or double tubes, respectively. [Please download the PDF file if you are unable to view the image below.]