Pre-exposure Prophylaxis (PrEP) Download PDF, 600KB, PDF Human Immunodeficiency Virus (HIV) Pre-Exposure Prophylaxis, or PrEP, is an oral medication (in the form of pills) that can prevent an HIV infection. If you have a high risk of acquiring HIV, you may be prescribed to take PrEP. Read on to find out more about PrEP and if you should take it. [Please download the PDF file if you are unable to view the image below.]