Research Grants and Publications

Grant Awards

A/Prof Rupesh Agrawal
2020

National Medical Research Council Clinician Scientist Award (NMRC CSA) Investigator Category

To establish a predictive artificial intelligence (AI) based model using immune-phenotype correlation for disease stratification and prognosis in patients with ocular tuberculosis (OTB)

Dr Wei Xin
2020

National Medical Research Council New Investigator Grant (NIG)

OCT based novel outcome measures in disease monitoring in ocular inflammatory and infectious diseases (OCTOMERIA)

A/Prof Rupesh Agrawal
2020

Ng Teng Fong Healthcare Innovation Programme (NTF HIP)

Development of web based application for self-assessment of functions of the eye (Eye Doctor in pocket - Poc Doc)

Featured Publications

WK Chee, CC Yip, L Yang, YK Soo, J Wang, BCM Chang

Assessing the Use of a Smartphone App to Teach Eye Screening to Opticians

Clin Teach. 2021 Jun;18(3):258-263. doi: 10.1111/tct.13310. Epub 2020 Dec 15
PMID: 33319490

Comparison of Polypoidal Choroidal Vasculopathy Lesion Sizes Measured on Multicolor Imaging and Indocyanine Green Angiography

Transl Vis Sci Technol. 2021 Feb; 10(2): 35. Published online 2021 Feb 23. doi: 10.1167/tvst.10.2.35
PMID: 34003920; PMCID: PMC7910643

Acute Onset of Bilateral Follicular Conjunctivitis in Two Patients with Confirmed SARS-CoV-2 Infections

Ocul Immunol Inflamm. 2020 Nov 16; 28(8):1280-1284. doi: 10.1080/09273948.2020.1821901. Epub 2020 Oct 6
PMID: 33021847

Collaborative Ocular Tuberculosis Study Consensus Guidelines on the Management of Tubercular Uveitis - Report 2: Guidelines for Initiating Antitubercular Therapy in Anterior Uveitis, Intermediate Uveitis, Panuveitis, and Retinal Vasculitis

Ophthalmology. 2021 Feb;128(2):277-287. doi: 10.1016/j.ophtha.2020.06.052. Epub 2020 Jun 27.

PMID: 32603726

Fructus lycii: A Natural Dietary Supplement for Amelioration of Retinal Diseases

Nutrients. 2021 Jan 16; 13(1):246. doi: 10.3390/nu13010246
PMID: 33467087; PMCID: PMC7830576

Visual Field Progression 8 Years after Trabeculectomy in Asian Eyes: Results from The Singapore 5-Fluorouracil Study

Br J Ophthalmol. 2020 Dec; 104(12):1690-1696. doi: 10.1136/bjophthalmol-2019-314121. Epub 2020 Mar 5
PMID: 32139502

Phacoemulsification versus Phacoemulsification with Micro-Bypass Stent Implantation in Primary Angle Closure and Primary Angle Closure Glaucoma: A Randomized Single-Masked Clinical Study

Clin Exp Ophthalmol. 2020 May; 48(4):450-461. doi: 10.1111/ceo.13721. Epub 2020 Feb 11
PMID: 32003538

Safety of 6000 Intravitreal Dexamethasone Implants

Br J Ophthalmol. 2020 Jan; 104(1):39-46. doi: 10.1136/bjophthalmol-2019-313991. Epub 2019 Apr 30
PMID: 31040132

Six-year Incidence and Progression of Diabetic retinopathy in Indian Adults: The Singapore Indian Eye Study

Br J Ophthalmol. 2019 Dec; 103(12):1732-1739. doi: 10.1136/bjophthalmol-2018-313282. Epub 2019 Feb 2
PMID: 30711921

Young's Modulus Determination of Normal and Glaucomatous Human Iris

Invest Ophthalmol Vis Sci. 2019 Jun 3; 60(7):2690-2695. doi: 10.1167/iovs.18-26455
PMID: 31242291

Incidence and Outcomes of Intraoperative Descemet Membrane Perforations during Deep Anterior Lamellar Keratoplasty

Am J Ophthalmol. 2019 Mar; 199:9-18. doi: 10.1016/j.ajo.2018.10.026. Epub 2018 Nov 1
PMID: 30391530

Choosing Anesthesia Options for Cataract Surgery in Patients with Dementia

J Anaesthesiol Clin Pharmacol. Jan-Mar 2019; 35(1):81-84. doi: 10.4103/joacp.JOACP_22_18 PMID: 31057246; PMCID: PMC6495616

Optical Coherence Tomography Angiography of Optic Disc and Macula Vessel Density In Glaucoma and Healthy Eyes

J Glaucoma. 2019 Jan; 28(1):80-87. doi: 10.1097/IJG.0000000000001125
PMID: 30461553

Choroidal Structural Changes and Vascularity Index in Stargardt Disease on Swept Source Optical Coherence Tomography

Retina. 2018 Dec; 38(12):2395-2400. doi: 10.1097/IAE.0000000000001879
PMID: 29016459

Trends in Cataract Surgery Technique and Anaesthesia Preferences in Singapore: A 2016 Survey

Ann Acad Med Singap. 2018 Sep; 47(9):390-393
PMID: 30324968

Choroidal Vascularity Index in Retinitis Pigmentosa: An OCT Study

Ophthalmic Surg Lasers Imaging Retina. 2018 Mar 1; 49(3):191-197. doi: 10.3928/23258160-20180221-07
PMID: 29554387

Ocular Autoimmune Systemic Inflammatory Infectious Study (OASIS) - Report 4: Analysis and Outcome of Scleritis in an East Asian Population

J Ophthalmic Inflamm Infect. 2017 Dec; 7(1):6. doi: 10.1186/s12348-017-0124-5. Epub 2017 Feb 15
PMID: 28205148; PMCID: PMC5311008

Choroidal Vascular Changes in Age-Related Macular Degeneration

Acta Ophthalmol. 2017 Nov; 95(7):e597-e601. doi: 10.1111/aos.13399. Epub 2017 Apr 9
PMID: 28391615

Purtscher-Like Retinopathy - A Rare Complication of Acute Myocardial Infarction and A Review of the Literature

Saudi J Ophthalmol. 2017 Oct-Dec; 31(4):250-256. doi: 10.1016/j.sjopt.2017.05.009. Epub 2017 May 22
PMID: 29234228; PMCID: PMC5717495

Giant Non-Pulsatile Polypoidal Choroidal Vasculopathy

Int J Ophthalmol. 2016 Dec 18; 9(12):1849-1851. doi: 10.18240/ijo.2016.12.26. eCollection 2016
PMID: 28003992; PMCID: PMC5155005

Prevalence of Latanoprost Intolerance and Subsequent Travoprost Tolerance in a Singaporean Population

Singapore Medical Journal 01-Aug-16 Volume 57 Supplement 1 Pages 59-60

Effect of Head Tilt on Repeatability of Optic Nerve Head Parameters Using Cirrus Spectral-Domain Optical Coherence Tomography

Int J Ophthalmol. 2016 Aug 18; 9(8):1170-5. doi: 10.18240/ijo.2016.08.14. eCollection 2016
PMID: 27585788; PMCID: PMC4990583

Inter-Eye Comparison of Retinal Oximetry and Vessel Caliber Between Eyes with Asymmetrical Glaucoma Severity in Different Glaucoma Subtypes

Clin Ophthalmol. 2016 Jul 19; 10:1315-21. doi: 10.2147/OPTH.S96529. eCollection 2016
PMID: 27486303; PMCID: PMC4958362

Flow Test to Predict Early Hypotony and Hypertensive Phase after Ahmed Glaucoma Valve (AGV) Surgical Implantation

J Glaucoma. 2016 Jun; 25(6):493-6. doi: 10.1097/IJG.0000000000000318
PMID: 26372153

A Novel Classification of the Vascular Patterns of Polypoidal Choroidal Vasculopathy and its Relation to Clinical Outcomes

Br J Ophthalmol. 2014 Nov; 98(11):1528-33. doi: 10.1136/bjophthalmol-2014-305059. Epub 2014 Jul 4
PMID: 24997181

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Grants and Publications

Grant Awards

A/Prof Rupesh Agrawal2020

National Medical Research Council Clinician Scientist Award (NMRC CSA) Investigator Category

Dr Wei Xin2020

National Medical Research Council New Investigator Grant (NIG)

A/Prof Rupesh Agrawal2020

Ng Teng Fong Healthcare Innovation Programme (NTF HIP)

A/Prof Rupesh Agrawal2020

Ng Teng Fong Healthcare Innovation Programme (NTF HIP)

Dr Kumari Neelam2019

Science - Translational & Applied Research (STAR) I/II Grant

Dr Kelvin Li2020

Tan Tock Seng Hospital Pitch-for-Fund Program (TTSH PFFP)

Dr Ngo Wei Kiong2019

Tan Tock Seng Hospital Pitch-for-Fund Program (TTSH PFFP)

A/Prof Colin Tan2019

Tan Tock Seng Hospital Pitch-for-Fund Program (TTSH PFFP)

Dr Louis Lim2021

Woodlands Health Centre Office of Research Development and Scholarship (WORDS) Small PROjects Utilising Teams (SPROUTS) Grant

Featured Publications

WK Chee, CC Yip, L Yang, YK Soo, J Wang, BCM Chang

Assessing the Use of a Smartphone App to Teach Eye Screening to Opticians

Louis W. Lim, Colin S. Tan, Dominic S. Ting

Comparison of Polypoidal Choroidal Vasculopathy Lesion Sizes Measured on Multicolor Imaging and Indocyanine Green Angiography

Louis W Lim, Glorijoy S Tan, Vernon Yong, Danielle E Anderson, David C Lye, Barnaby Young, Rupesh Agrawal

Acute Onset of Bilateral Follicular Conjunctivitis in Two Patients with Confirmed SARS-CoV-2 Infections

Collaborative Ocular Tuberculosis Study Consensus Guidelines on the Management of Tubercular Uveitis - Report 2: Guidelines for Initiating Antitubercular Therapy in Anterior Uveitis, Intermediate Uveitis, Panuveitis, and Retinal Vasculitis

Ophthalmology. 2021 Feb;128(2):277-287. doi: 10.1016/j.ophtha.2020.06.052. Epub 2020 Jun 27.

Kumari Neelam, Sonali Dey, Ralene Sim, Jason Lee, Kah-Guan Au Eong

Fructus lycii: A Natural Dietary Supplement for Amelioration of Retinal Diseases

Bryan CH Ang, Sophia Seen, Arjunan Kumaran, John Mark Sim De Leon, Steve Kah Leng Seah, Paul J Foster, Gus Gazzard , Hla M Htoon, Peng Tee Khaw , Tin Aung, Rahat Husain

Visual Field Progression 8 Years after Trabeculectomy in Asian Eyes: Results from The Singapore 5-Fluorouracil Study

David Z Chen, Chelvin CA Sng, Tiakumzuk Sangtam, Anoop Thomas, Liang Shen, Philemon K Huang, Jason Cheng

Phacoemulsification versus Phacoemulsification with Micro-Bypass Stent Implantation in Primary Angle Closure and Primary Angle Closure Glaucoma: A Randomized Single-Masked Clinical Study

Tock H Lim, Timothy YY Lai, Kanji Takahashi, Tien Y Wong, Lee-Jen Chen, Paisan Ruamviboonsuk, Colin S Tan, Won Ki Lee, Chui Ming Gemmy Cheung, Nor Fariza Ngah, Ramune Patalauskaite, Philippe Margaron, Adrian Koh, EVEREST II Study Group

Comparison of Ranibizumab With or Without Verteporfin Photodynamic Therapy for Polypoidal Choroidal Vasculopathy: The EVEREST II Randomized Clinical Trial

JAMA Ophthalmol. 2020 Sep 1;138(9):935-942. doi: 10.1001/jamaophthalmol.2020.2443

Philip Francis Stanley

An Intraocular Eyelash after Uneventful Cataract Surgery

Ee Ping Ong, Jun Cheng, Damon WK Wong, Elton LT Tay, Hwei Yee Teo, Rosalyn Grace Loo, Leonard WL Yip

Automatic Glaucoma Detection from Stereo Fundus Images

Jeremy Y Hu, Bryan CH Ang, Leonard W Yip

Efficacy of the XEN Gel Stent on Intraocular Pressure Lowering in East Asian Eyes

Rupesh Agrawal, Jianbin Ding, Parveen Sen, Andres Rousselot, Amy Chan, Lisa Nivison-Smith, Xin Wei, Sarakshi Mahajan, Ramasamy Kim, Chitaranjan Mishra, Manisha Agarwal, Min Hee Suh, Saurabh Luthra, Marion R Munk, Carol Y Cheung, Vishali Gupta, CVI.grid

Exploring Choroidal Angioarchitecture in Health and Disease Using Choroidal Vascularity Index

JAMA Ophthalmol. 2020 Sep 1;138(9):935-942. doi: 10.1001/jamaophthalmol.2020.2443

Safety of 6000 Intravitreal Dexamethasone Implants

Neelam Kumari, Mayuri Bhargava , Duc Quang Nguyen, Alfred Tau Liang Gan, Gavin Tan, Ning Cheung, Nicholas Tan, Charlene Wong, Jie Jin Wang, Paul Mitchell, Ecosse L Lamoureux , Ching Yu Cheng , Tien Yin Wong, Charumathi Sabanayagam

Six-year Incidence and Progression of Diabetic retinopathy in Indian Adults: The Singapore Indian Eye Study

Arun Narayanaswamy, Mui Hoon Nai, Monisha E Nongpiur, Hla Myint Htoon, Anoop Thomas, Tiakumzuk Sangtam, Chwee Teck Lim, Tina T Wong, Tin Aung

Young's Modulus Determination of Normal and Glaucomatous Human Iris

Jason Kian Seng Lee, Mei-Xue Loi, Yi-Hsuan Wei, Shu-Lang Liao

Optimizing Esthetic Outcomes in Graded Full-thickness Anterior Blepharotomy for Graves' Ophthalmopathy

Graefes Arch Clin Exp Ophthalmol. 2019 Jun; 257(6):1303-1308. doi: 10.1007/s00417-019-04308-z. Epub 2019 Apr 2

Olivia S Huang, Hla M Htoon, Amy M Chan, Donald Tan, Jodhbir S Mehta

Incidence and Outcomes of Intraoperative Descemet Membrane Perforations during Deep Anterior Lamellar Keratoplasty

Chandra M Kumar, Lekha Gopal, Edwin Seet

Choosing Anesthesia Options for Cataract Surgery in Patients with Dementia

Vivien CH Yip, Hon Tym Wong, Vernon KY Yong, Boon Ang Lim, Owen K Hee, Jun Cheng, Huazhu Fu, Chingwei Lim, Elton LT Tay, Roselyn G Loo-Valdez, Hwei Yee Teo, Angela Lim PH, Leonard WL Yip

Optical Coherence Tomography Angiography of Optic Disc and Macula Vessel Density In Glaucoma and Healthy Eyes

Jason Kian Seng Lee, Chen Hsieh, Yi-Hsuan Wei, Shu-Lang Liao

The Impact of Orbital Bony or Fat Decompression on the Outcome of Strabismus Surgery in Patients with Graves' Ophthalmopathy

J Formos Med Assoc. 2019 Jan; 118(1 Pt 3):387-394. doi: 10.1016/j.jfma.2018.06.009. Epub 2018 Jul 7

Dhanashree Ratra, Roy Tan, Durgasri Jaishankar, Neha Khandelwal, Arushi Gupta, Jay Chhablani, Rupesh Agrawal

Choroidal Structural Changes and Vascularity Index in Stargardt Disease on Swept Source Optical Coherence Tomography

Yong Seng Tam, Chandra M Kumar, Kah Guan Au Eong, Chee Chew Yip, Jason Cheng

Trends in Cataract Surgery Technique and Anaesthesia Preferences in Singapore: A 2016 Survey

Roy Tan, Rupesh Agrawal, Swathi Taduru, Arushi Gupta, Kiran Vupparaboina, Jay Chhablani

Choroidal Vascularity Index in Retinitis Pigmentosa: An OCT Study

Xiao Zhang, Wai Kitt Chee, Sylvia Liu, Subramaniam Tavinthara, Chee Fang Sum, Su Chi Lim, Neelam Kumari

Association of Plasma Osteopontin with Diabetic Retinopathy in Asians with Type 2 Diabetes

Mol Vis. 2018 Feb 15; 24:165-173. eCollection 2018

Muhammad Amir Bin Ismail, Rachel Hui Fen Lim, Helen Mi Fang, Elizabeth Poh Ying Wong, Ho Su Ling, Wee Kiak Lim, Stephen C Teoh, Rupesh Agrawal

Ocular Autoimmune Systemic Inflammatory Infectious Study (OASIS) - Report 4: Analysis and Outcome of Scleritis in an East Asian Population

Lilian Hui Li Koh, Rupesh Agrawal, Neha Khandelwal, Labishetty Sai Charan, Jay Chhablani

Choroidal Vascular Changes in Age-Related Macular Degeneration

Leslie Jonathan Pek Seng Ang, Benjamin Chong Ming Chang

Purtscher-Like Retinopathy - A Rare Complication of Acute Myocardial Infarction and A Review of the Literature

Srinivasan Sanjay, Hah Yan Yee, Benjamin Chang Chong Ming, Yip Chee Chew, Alvin Wong Seng Cheong, Thomas Choudary Putti

A/Prof Rupesh Agrawal
2020

Dr Wei Xin
2020

A/Prof Rupesh Agrawal
2020

A/Prof Rupesh Agrawal
2020

Dr Kumari Neelam
2019

Dr Kelvin Li
2020

Dr Ngo Wei Kiong
2019

A/Prof Colin Tan
2019

Dr Louis Lim
2021